Description

Cyclo(glycyl-L-leucyl) (Cyclo(leu-gly)), a neuropeptide, down-regulates dopamine (DA) receptors and attenuates dopaminergic supersensitivity. Cyclo(glycyl-L-leucyl) inhibits the development of Morphine induced pain relief as well as dopamine receptor supersensitivity in rats. Cyclo(glycyl-L-leucyl) has the potential for the prevention of tardive and/or L-DOPA (HY-N0304)-induced dyskinesias[1][2].—–C8H14N2O2—-[1]J Z Fields, et al. The effects of cyclo(leucyl-glycyl) on nigrostriatal dopaminergic supersensitivity–inhibition of apomorphine-induced climbing. Neuropeptides. 1990 Aug;16(4):207-11.|[2]H N Bhargava, et al. Cyclo (leucylglycine) inhibits the development of morphine induced analgesic tolerance and dopamine receptor supersensitivity in rats. Life Sci. 1980 Jul 14;27(2):117-23.–5845-67-0–170.21—-CC(C[C@H]1C(NCC(N1)=O)=O)C–Neurological Disease–H2O–Dopamine Receptor–Dopamine Receptor–GPCR/G Protein;Neuronal Signaling–Peptides