Description

Cortistatin 14, human, rat (CST-14, human, rat), a neuropeptide with neuronal depressant and sleep modulating properties, can bind to all five cloned somatostatin receptors (SSTRs) and ghrelin receptor to exert its biological activities and co-exists with GABA within the cortex and hippocampus[1][2].—Neuroscience-Neuromodulation–C81H113N19O19S2—-[1]Jiang J, et al. Centrally Administered Cortistation-14 Induces Antidepressant-Like Effects in Mice via MediatingGhrelin and GABAA Receptor Signaling Pathway. Front Pharmacol. 2018 Jul 19;9:767.|[2]de Lecea L, et al. A cortical neuropeptide with neuronal depressant and sleep-modulating properties. Nature. 1996 May 16;381(6579):242-5.–193829-96-8–1721.01—-[H]N1CCC[C@H]1C(N[C@H]2CSSC[C@@H](C(N[C@H](C(O)=O)CCCCN)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]([C@H](O)C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC2=O)CCCCN)=O)CC(N)=O)=O)CC3=CC=CC=C3)=O)CC4=CC=CC=C4)=O)CC5=CNC6=C5C=CC=C6)=O)CCCCN)=O)=O)CC7=CC=CC=C7)=O)CO)=O)CO)=O)=O–Neurological Disease–10 mM in DMSO–Somatostatin Receptor—-GPCR/G Protein;Neuronal Signaling–Peptides