Conantokin R-Get quote

Description

Conantokin R (Con-R) is an NMDA receptor peptide antagonist with an IC50 of 93 nM. Conantokin R binds Zn2+ and Mg2+ with Kds of 0.15 μM and 6.5 μM, respectively. Conantokin R shows anticonvulsant activity[1][2].—–C127H201N35O49S3—-[1]Blandl T, et al. Structure-function relationships of the NMDA receptor antagonist peptide, conantokin-R. FEBS Lett. 2000 Mar 24;470(2):139-46.|[2]White HS, et al. In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus. J Pharmacol Exp Ther. 2000 Jan;292(1):425-32.–202925-60-8–3098.35—-OC(C=C1)=CC=C1C[C@H](NC([C@H]2NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CSSC2)NC(CNC([C@H](CCCCN)NC([C@H](C)NC([C@H]([C@@H](C)CC)NC([C@H](CC(N)=O)NC([C@H](CC(C(O)=O)C(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](C)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](C)NC([C@H](C)NC([C@H](CCSC)NC([C@H](CCCCN)NC([C@H](C)NC([C@H](C(C)C)NC([C@H](CC(C(O)=O)C(O)=O)NC([C@H](CC(C(O)=O)C(O)=O)NC([C@H](CCC(O)=O)NC(CN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC(C(O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCCCN)=O)C(C)C)=O)CC(N)=O)=O)=O)C(N3[C@@H](CCC3)C(O)=O)=O–Neurological Disease–10 mM in DMSO–iGluR—-Membrane Transporter/Ion Channel;Neuronal Signaling–Peptides