Description

Chlamydocin, a fungal metabolite, is a highly potent HDAC inhibitor, with an IC50 of 1.3 nM. Chlamydocin exhibits potent antiproliferative and anticancer activities. Chlamydocin induces apoptosis by activating caspase-3[1].—Cancer-programmed cell death–C28H38N4O6—-[1]De Schepper S, et al. Inhibition of histone deacetylases by chlamydocin induces apoptosis and proteasome-mediated degradation of survivin. J Pharmacol Exp Ther. 2003;304(2):881-888.–53342-16-8–526.62—-O=C1N2[C@@]([H])(C(N[C@@H](CCCCCC([C@@H]3CO3)=O)C(NC(C)(C(N[C@]1(CC4=CC=CC=C4)[H])=O)C)=O)=O)CCC2–Cancer–10 mM in DMSO–Apoptosis;HDAC–HDAC–Apoptosis;Cell Cycle/DNA Damage;Epigenetics–Peptides