Description

Celecoxib-d4 is the deuterium labeled Desmethyl Celecoxib. Desmethyl Celecoxib (compound 3b) is a selective cyclooxygenase-2 (COX-2) inhibitor (IC50=32 nM) with anti-inflammatory activities. Desmethyl Celecoxib is an analog of Celecoxib and with the optimal yield of 75%[1].–20°C, 3 years; 4°C, 2 years (Powder)-Applications–Formula-C17H10D4F3N3O2S-Citation–References-[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Vinay Kumar Sthalam, et al. An Integrated Continuous Flow Micro-Total Ultrafast Process System (μ-TUFPS) for the Synthesis of Celecoxib and Other Cyclooxygenase Inhibitors. RETURN TO ISSUEPREVARTICLENEXT-CASNumber-544686-20-6-MolecularWeight-385.40-Compound Purity–SMILES-FC(F)(C1=NN(C2=C([2H])C([2H])=C(C([2H])=C2[2H])S(N)(=O)=O)C(C3=CC=C(C=C3)C)=C1)F-Research_Area-Inflammation/Immunology-Solubility-10 mM in DMSO-Target-COX;Isotope-Labeled Compounds-Isoform–Pathway-Immunology/Inflammation;Others-MCE Product type-Isotope-Labeled Compounds