Description

:PE-Cy7;host:Rabbit;target_protein:Caspase-9;modification:Unmodified;clonality:Polyclonal;isotype:IgG;concentration:1ug/ul;subcellular_locations:Cytoplasm, Nucleus;source:KLH conjugated synthetic peptide derived from human Caspase-9 subunit p35;gene_id:842;swiss_prot:P55211;applications_with_dilutions:WB(1:300-5000), FCM(1:20-100);cross_reactive_species:Human, Mouse, Rat;predicted_cross_reactive_species:;background:Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.;purification:Purified by Protein A.;storage_buffer:Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.;storage_condition:Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.;:488nm/780nm;synonyms:MCH6; APAF3; APAF-3; PPP1R56; ICE-LAP6; Caspase-9; CASP-9; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; ICE-like apoptotic protease 6; CASP9