Description

c[Arg-Arg-Arg-Arg-Dip-Dip-Dip] (Compound 8C) shows broad-spectrum activity against drug-resistant Gram-positive and Gram-negative bacteria, with MICs of 3.1, 3,1, 12.5, and 12.5 μg/mL for MRSA (ATCC BAA-1556), S. aureus (ATCC 29213), P. aeruginosa (ATCC 27883), and E. coli (ATCC 25922), respectively[1].—COVID-19-immunoregulation–C69H87N19O7—-[1]Sandeep Lohan, et al. Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties. J Med Chem. 2022 Jan 13;65(1):665-687.–2619853-87-9–1294.55—-O=C(N[C@H](C(N[C@@H](C(N[C@@H](C1=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)C(C2=CC=CC=C2)C3=CC=CC=C3)[C@@H](NC([C@@H](NC([C@H](NC([C@H](N1)CCCNC(N)=N)=O)CCCNC(N)=N)=O)C(C4=CC=CC=C4)C5=CC=CC=C5)=O)C(C6=CC=CC=C6)C7=CC=CC=C7–Infection–10 mM in DMSO–Bacterial—-Anti-infection–Peptides