Description

Brigimadlin intermediate-1 is an intermediate of the E3 ubiquitin protein ligase MDM-2 inhibitor Brigimadlin (HY-152859) and can be used to synthesize Antibody-Drug Conjugates (ADCs) .–Applications–Formula-C9H10N2O4-Citation–References-[1]Gollner Andreas, et al. Preparation of spiroindolepyrrolidinone derivatives for use as MDM2-p53 inhibitors: World Intellectual Property Organization, WO2017060431. 2017-04-13.|[2]WHO Drug Information-World Health Organization (WHO).|[3]Hao X, et al. BI-907828, a novel potent MDM2 inhibitor, inhibits glioblastoma brain tumor stem cells in vitro and prolongs survival in orthotopic xenograft mouse models. Neuro Oncol. 2023 May 4;25(5):913-926.-CASNumber-1149388-04-4-MolecularWeight-210.19-Compound Purity–SMILES-O=C(OC)C1=CC=C(N)C([N+]([O-])=O)=C1C-Research_Area-cancer-Solubility-10 mM in DMSO-Target-Others-Isoform–Pathway-Others-MCE Product type-ADC Related