Description

BACE1-IN-10 is a potent BACE1 Inhibitor. BACE1-IN-10 shows sub-micromolar activity against recombinant BACE1 (rBACE1)[1].—Neuroscience-Neurodegeneration–C33H49N5O8S—-[1]Kazuya Kobayashi, et al. Structure-activity relationship study of hydroxyethylamine isostere and P1′ site structure of peptide mimetic BACE1 inhibitors. Bioorg Med Chem. 2021 Nov 15;50:116459.–2799658-44-7–675.84—-CC[C@@H]([C@@H](C(N[C@H](C(N[C@H]([C@@H](CNC1=CC=C(C=C1)CC(O)=O)O)CC(C)C)=O)CC2=CC=CS2)=O)NC([C@H](CCC(O)=O)N)=O)C–Cancer–10 mM in DMSO–Beta-secretase–BACE1–Neuronal Signaling–Peptides