Description

AY77 is a calcium-biased PAR2 agonist. AY77 shows an EC50 of 0.17 and 2 nM in PAR2-mediated the activation in the Gq pathway and recruitment of β-arrestin-2, respectively. AY77 potently induces intracellular Ca2+ release[1][2].—–C21H32N4O4—-[1]Klösel I, et al. Discovery of Novel Nonpeptidic PAR2 Ligands. ACS Med Chem Lett. 2020 May 22;11(6):1316-1323.|[2]Jiang Y, et al. Biased Signaling by Agonists of Protease Activated Receptor 2. ACS Chem Biol. 2017 May 19;12(5):1217-1226.–1835734-92-3–404.50—-O=C(N)[C@H](C1CCCCC1)NC([C@H](CC2CCCCC2)NC(C3=CC=NO3)=O)=O–Cancer; Inflammation/Immunology–10 mM in DMSO–Protease Activated Receptor (PAR)—-GPCR/G Protein–Peptides