Description

AY254 is an analogue of AY77 (HY-138951). AY254 is ERK-biased PAR2 agonist with an EC50 of 2 nM. AY254 relieves cytokine-induced caspase 3/8 activation. AY254 also promotes scratch-wound healing and induced IL-8 secretion via PAR2-ERK1/2 signaling[1]—–C30H49N9O6—-[1]Jiang Y, et al. Biased Signaling by Agonists of Protease Activated Receptor 2. ACS Chem Biol. 2017 May 19;12(5):1217-1226.–2093408-03-6–631.77—-O=C(C1=CC=NO1)N[C@@H](CC2CCCCC2)C(N[C@@H](C3CCCCC3)C(N[C@@H](C)C(N[C@H](C(N)=O)CCCNC(N)=N)=O)=O)=O–Cancer; Inflammation/Immunology–10 mM in DMSO–Protease Activated Receptor (PAR)—-GPCR/G Protein–Peptides