ATX-II (TFA)-100 μg

Description

ATX-II TFA is a specific Na+ channel Modulator toxin that can be isolated from the venom of sea anemone (Anemonia sulcata). ATX-II TFA causes delayed inactivation of the Na+</sup channel in cell cultures. ATX-II TFA sensitizes skeletal muscle to Halothane (HY-B1010), Caffeine, and Ryanodine (HY-103306). ATX-II TFA also induces pulmonary vein arrhythmogenesis and atrial fibrillation[1][2].–80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)–COVID-19-immunoregulation–C213H323N63O61S6.xC2HF3O2—-[1]Fletcher JE, et al. ATX II, a sodium channel toxin, sensitizes skeletal muscle to halothane, caffeine, and ryanodine. Anesthesiology. 1999 May;90(5):1294-301.|[2]Lu YY, et al. ATX-II-induced pulmonary vein arrhythmogenesis related to atrial fibrillation and long QT syndrome. Eur J Clin Invest. 2012 Aug;42(8):823-31.—-4934.62 (free acid)–99.84–O=C(N[C@@H](C(C)C)C(N1[C@@H](CCC1)C(N[C@@H](CSSC[C@@H]2NC3=O)C(N[C@@H](CC(C)C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC4=CNC=N4)C(NCC(N5[C@@H](CCC5)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@H]3CC6=CNC7=CC=CC=C67)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC8=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(NCC(N9[C@@H](CCC9)C(N[C@@H](CO)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC=CNC=CC=CC=C)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(NCC(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(O)=O)=O)=O)NC2=O)C(N[C@@H](CCC)C(N[C@@H](CO)C(NCC(N[C@@H](CC=CNC=CC=CC=C)C(N[C@@H](CC=CNC=N)C(N[C@H]8CC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN.OC(C(F)(F)F)=O.[x]–Inflammation/Immunology–H2O : 100 mg/mL (ultrasonic)–Sodium Channel—-Membrane Transporter/Ion Channel–Peptides