Description
Astressin 2B TFA is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist, with the IC50 values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. Astressin 2B TFA antagonizes CRF2-mediated inhibition of gastric emptying[1][2][3].–80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)—-C183H307N49O53.xC2HF3O2—-[1]Rivier J, et al. Potent and long-acting corticotropin releasing factor (CRF) receptor 2 selective peptide competitive antagonists. J Med Chem. 2002;45(21):4737-4747.|[2]Henry B, et al. The effect of lateral septum corticotropin-releasing factor receptor 2 activation on anxiety is modulated by stress. J Neurosci. 2006;26(36):9142-9152.|[3]Hoare SR, et al. Peptide ligand binding properties of the corticotropin-releasing factor (CRF) type 2 receptor: pharmacology of endogenously expressed receptors, G-protein-coupling sensitivity and determinants of CRF2 receptor selectivity. Peptides. 2005;26(3):457-470.—-4041.69 (free base)–99.35–O=C([C@H](CCCCNC1=O)NC([C@H](CCC(N[C@H](C(N[C@H]1CC(N)=O)=O)CC(N)=O)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@](C)(NC([C@@H](NC([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(C)=O)CC(O)=O)=O)CC(C)C)=O)CO)=O)CC2=CC=CC=C2)=O)CC3=CNC=N3)=O)CC(C)C)=O)CC(C)C)=O)CCCNC(N)=N)=O)CCCCN)=O)CCCC)=O)[C@H](CC)C)=O)CCC(O)=O)=O)[C@H](CC)C)=O)CCC(O)=O)=O)CCCCN)=O)CCC(N)=O)=O)CCC(O)=O)=O)CCCCN)=O)CCC(O)=O)=O)CCCCN)=O)CCC(N)=O)=O)CCC(N)=O)=O)C)=O)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@](C)(C(N[C@H](C(N)=O)[C@H](CC)C)=O)CC(C)C)=O)CC(O)=O)=O)CC(C)C)=O)CC(C)C)=O)CC(C)C.OC(C(F)(F)F)=O.[x]–Others–10 mM in DMSO–CFTR—-Membrane Transporter/Ion Channel–Peptides
