Description

:ALEXA FLUOR® 750;host:Rabbit;target_protein:APAF1CT;modification:Unmodified;clonality:Polyclonal;isotype:IgG;concentration:1ug/ul;subcellular_locations:Cytoplasm;source:KLH conjugated synthetic peptide derived from human Apaf-1;gene_id:317;swiss_prot:O14727;applications_with_dilutions:WB(1:300-5000), IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200);cross_reactive_species:Human, Rat, Zebrafish;predicted_cross_reactive_species:Mouse, Dog, Horse;background:Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.;purification:Purified by Protein A.;storage_buffer:Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.;storage_condition:Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.;:749nm/775nm;synonyms:CED4; APAF-1; Apoptotic protease-activating factor 1; APAF1; KIAA0413