Description

Anticancer agent 81 (Compound 37b3) is an anticancer agent and can induce tumor cell cycle arrest and apoptosis. Anticancer agent 81 can be used as a payload to conjugate with Trastuzumab (HY-P9907) to obtain the antibody–agent conjugate (ADC) T-PBA. T-PBA maintained its mode of target and internalization ability of Trastuzumab[1].–Applications-Cancer-programmed cell death-Formula-C46H46N6O5-Citation–References-[1]Lai W, et al. Design, Synthesis, and Bioevaluation of a Novel Hybrid Molecular Pyrrolobenzodiazepine-Anthracenecarboxyimide as a Payload for Antibody-Drug Conjugate. J Med Chem. 2022 Aug 18.-CASNumber-2820286-56-2-MolecularWeight-762.89-Compound Purity–SMILES-O=C1N(CCN2CCN(CCCCCOC3=C(OC)C=C4C(N=C[C@@](CC(C5=CC=C(N)C=C5)=C6)([H])N6C4=O)=C3)CC2)C(C7=CC=CC8=CC9=CC=CC=C9C1=C78)=O-Research_Area-Cancer-Solubility-10 mM in DMSO-Target-ADC Cytotoxin;Apoptosis-Isoform–Pathway-Antibody-drug Conjugate/ADC Related;Apoptosis-MCE Product type-ADC Related