Description

Amyloid 17-42 (Aβ(17-42)) is a major constituent of diffuse plaques in Alzheimer’s disease and cerebellar pre-amyloid in Down’s syndrome, derived by alpha- and gamma-secretase cleavage of the amyloid precursor protein (APP). Amyloid 17-42 can induce neuronal apoptosis via a Fas-like/caspase-8 activation pathway[1].—–C119H194N28O33S—-[1]Wanli Wei, et al. Abeta 17-42 in Alzheimer’s disease activates JNK and caspase-8 leading to neuronal apoptosis. Brain. 2002 Sep;125(Pt 9):2036-43. –155178-13-5–2577.05—-OC([C@H](C)NC([C@H]([C@@H](C)CC)NC([C@H](C(C)C)NC([C@H](C(C)C)NC(CNC(CNC([C@H](C(C)C)NC([C@H](CCSC)NC([C@H](CC(C)C)NC(CNC([C@H]([C@@H](C)CC)NC([C@H]([C@@H](C)CC)NC([C@H](C)NC(CNC([C@H](CCCCN)NC([C@H](CC(N)=O)NC([C@H](CO)NC(CNC([C@H](C(C)C)NC([C@H](CC(O)=O)NC([C@H](CCC(O)=O)NC([C@H](C)NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@H](C(C)C)NC([C@@H](N)CC(C)C)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O–Neurological Disease–10 mM in DMSO–Apoptosis—-Apoptosis–Peptides