Description

Aminohexylgeldanamycin (AHGDM) hydrochloride, a Geldanamycin derivative, is a potent HSP90 inhibitor. Aminohexylgeldanamycin hydrochloride shows antiangiogenic and antitumor activities[1].–Applications-Cancer-programmed cell death-Formula-C34H53ClN4O8-Citation–References-[1]Greish K, et al. Anticancer and antiangiogenic activity of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer therapy. J Control Release. 2011;151(3):263-270.|[2]Larson N, et al. HPMA copolymer-aminohexylgeldanamycin conjugates targeting cell surface expressed GRP78 in prostate cancer. Pharm Res. 2010;27(12):2683-2693.-CASNumber-1146534-45-3-MolecularWeight-681.26-Compound Purity–SMILES-[H]Cl.O=C(C(NCCCCCCN)=C1C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=CC=C(C)C2=O)C=C(N2)C1=O-Research_Area-Cancer-Solubility-10 mM in DMSO-Target-ADC Cytotoxin;HSP-Isoform-HSP90-Pathway-Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease-MCE Product type-ADC Related