Description

Aminohexylgeldanamycin (AHGDM), a Geldanamycin derivative, is a potent HSP90 inhibitor. Aminohexylgeldanamycin shows antiangiogenic and antitumor activities[1].–20°C (Powder, protect from light)-Applications-Cancer-programmed cell death-Formula-C34H52N4O8-Citation–References-[1]Larson N, et al. HPMA copolymer-aminohexylgeldanamycin conjugates targeting cell surface expressed GRP78 in prostate cancer. Pharm Res. 2010;27(12):2683-2693.|[2]Greish K, et al. Anticancer and antiangiogenic activity of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer therapy. J Control Release. 2011;151(3):263-270.-CASNumber-485395-71-9-MolecularWeight-644.80-Compound Purity-99.82-SMILES-O=C(C(NCCCCCCN)=C1C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=CC=C(C)C2=O)C=C(N2)C1=O-Research_Area-Cancer-Solubility-DMSO : 110 mg/mL (ultrasonic)-Target-ADC Cytotoxin;HSP-Isoform-HSP90-Pathway-Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease-MCE Product type-ADC Related