Description

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 is a biological active peptide. (Protease activated receptor 1 (PAR-1) belongs to a subfamily of G-protein coupled receptors and is known to mediate the cellular effects of thrombin. This peptide is a PAR-1 selective agonist displaying a high level of specificity to PAR-1 over PAR-2. The specificity of peptide was evaluated in cell-based calcium signaling assay using HEK293 cells. PAR-1 selective agonists can be used to study PAR-1 activation in vivo. In addition to its varied cellular effects of thrombin, PAR-1 has also been shown to coordinate with PAR-4 and regulate thrombin-induced hepatocellular carcinoma harboring thrombin formation within the tumor environment classified as ‘coagulation type’.)—–C42H63FN12O8——211190-38-4–883.02—-O=C(N[C@@H](CC1=CC=C(F)C=C1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC2CCCCC2)C(N[C@@H](CCCNC(N)=O)C(N[C@@H](CC3=CC=C(C=C3)O)C(N)=O)=O)=O)=O)=O)[C@H](C)N–Others–10 mM in DMSO–Protease Activated Receptor (PAR)—-GPCR/G Protein–Peptides