Agitoxin-2 (TFA)-Get quote

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Agitoxin-2 TFA is a K+ channel inhibitor, with IC50 values of 201 pM and 144 pM for mKV1.3 and mKV1.1, respectively)[1][2].—Neuroscience-Neuromodulation–C169H278N54O48S8.xC2HF3O2—-[1]M L Garcia, et al. Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus quinquestriatus var. hebraeus venom. Biochemistry. 1994 Jun 7;33(22):6834-9.|[2]Raveendra Anangi, et al. Recombinant expression of margatoxin and agitoxin-2 in Pichia pastoris: an efficient method for production of KV1.3 channel blockers.—-4090.87 (free acid)—-OC(C(F)(F)F)=O.O=C(N[C@@H](C(C)C)C(N1[C@@H](CCC1)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCSC)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H]2CCCCN)=O)=O)=O)=O)NC3=O)C(N[C@@H]([C@H](O)C)C(NCC(N[C@@H](CO)C(N4[C@@H](CCC4)C(N[C@@H](CCC(N)=O)C(N[C@@H](CSSC[C@@H](C(N[C@H]5CC6=CNC=N6)=O)NC2=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N7[C@@H](CCC7)C(N[C@@H](CSSC[C@@H](C(N[C@@H]([C@H](O)C)C(N8[C@@H](CCC8)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)NC5=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@@H](C)C(NCC(N[C@@H](CCSC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC9=CC=CC=C9)C(NCC(N[C@H]3CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN–Neurological Disease–H2O–Potassium Channel—-Membrane Transporter/Ion Channel–Peptides