Description

Ac9-25 TFA, a N-terminal peptide of Annexin I, acts as a formyl peptide receptor (FPR) agonist and activates the neutrophil NADPH oxidase through FPR[1][2].—COVID-19-immunoregulation–C99H143N23O33.xC2HF3O2—-[1]Walther A, et al. A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR. Mol Cell. 2000;5(5):831-840.|[2]Karlsson J, et al. Neutrophil NADPH-oxidase activation by an annexin AI peptide is transduced by the formyl peptide receptor (FPR), whereas an inhibitory signal is generated independently of the FPR family receptors. J Leukoc Biol. 2005;78(3):762-771.—-2183.33 (free acid)—-OC1=CC=C(C[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CNC3=CC=CC=C23)NC([C@@H](NC([C@H](CCC(N)=O)NC(C)=O)=O)C)=O)=O)CC4=CC=CC=C4)=O)[C@H](CC)C)=O)CCC(O)=O)=O)CC(N)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)CCC(N)=O)=O)CCC(O)=O)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(O)=O)=O)C(C)C)=O)[C@@H](C)O)=O)CCC(N)=O)=O)C(C)C)=O)C=C1.OC(C(F)(F)F)=O.[x]–Inflammation/Immunology–10 mM in DMSO–Formyl Peptide Receptor (FPR)—-GPCR/G Protein–Peptides