Ac-Trp-Glu-His-Asp-Aldehyde-Get quote

Description

Ac-Trp-Glu-His-Asp-Aldehyde is a potent and selective caspase-1 inhibitor with a Ki value of 56 pM[1][2].—COVID-19-immunoregulation–C28H33N7O9—-[1]Kindermann M, et al. Selective and sensitive monitoring of caspase-1 activity by a novel bioluminescent activity-based probe. Chem Biol. 2010 Sep 24;17(9):999-1007. |[2]Rano TA, et al. A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE). Chem Biol. 1997 Feb;4(2):149-55. –189275-71-6–611.60—-OC(C[C@@H](C=O)NC([C@H](CC1=CN=CN1)NC([C@H](CCC(O)=O)NC([C@@H](NC(C)=O)CC2=CNC3=CC=CC=C23)=O)=O)=O)=O–Inflammation/Immunology–10 mM in DMSO–Caspase–Caspase 1–Apoptosis–Peptides