Ac-RYYRWK-NH2 (TFA)-Get quote

Description

Ac-RYYRWK-NH2 is a potent and selective partial agonist for the nociceptin receptor (NOP), [3H]Ac-RYYRWK-NH2 binds to rat cortical membranes ORL1 with a Kd of 0.071 nM, but has no affinity for µ-, κ- or δ-opioid receptors[1].—Neuroscience-Neuromodulation–C51H70F3N15O11—-[1]C T Dooley, et al. Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1.J Pharmacol Exp Ther. 1997 Nov;283(2):735-41.|[2]M Ho, et al, Characterization of the ORL(1) receptor on adrenergic nerves in the rat anococcygeus muscle. Br J Pharmacol. 2000 Sep;131(2):349-55.–408305-09-9–1126.19—-OC(C(F)(F)F)=O.OC(C=C1)=CC=C1C[C@H](NC([C@@H](NC([C@@H](NC(C)=O)CCCNC(N)=N)=O)CC2=CC=C(C=C2)O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N)=O)CCCCN)=O)CC3=CNC4=CC=CC=C34)=O)=O–Neurological Disease–10 mM in DMSO–Opioid Receptor–NOP Receptor/ORL1–GPCR/G Protein;Neuronal Signaling–Peptides