Description

Ac-Pro-Gly-Pro-OH is an endogenous degradation product of extracellular collagen and can be used as CXCR2 agonist. Ac-Pro-Gly-Pro-OH elicits bactericidal activity and inhibits lung inflammation, reducing immune cell apoptosis. Ac-Pro-Gly-Pro-OH enhances the production of type 1 cytokines (IFN-γ and IL-12) but inhibits the production of proinflammatory cytokines. Ac-Pro-Gly-Pro-OH has the potential for the research of sepsis[1][2].—–C14H21N3O5—-[1]Patel DF, et al The multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease. Eur Respir Rev. 2018 Jun 27;27(148):180017.|[2]Kim SD, et al. Activation of CXCR2 by extracellular matrix degradation product acetylated Pro-Gly-Pro has therapeutic effects against sepsis. Am J Respir Crit Care Med. 2011 Jul 15;184(2):243-51.–292171-04-1–311.33—-O=C(N1[C@@H](CCC1)C(O)=O)CNC([C@H]2N(CCC2)C(C)=O)=O–Inflammation/Immunology–10 mM in DMSO–CXCR–CXCR2–GPCR/G Protein;Immunology/Inflammation–Peptides