Ac-Leu-Val-Lys-Aldehyde-Get quote

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Ac-Leu-Val-Lys-Aldehyde is a potent cathepsin B inhibitor with IC50s of 4 nM. Ac-Leu-Val-Lys-Aldehyde significantly reduces quinolinic acid (HY-100807)-induced striatal cell death and causes accumulation of LC3-II[1].—Neuroscience-Neuromodulation–C19H36N4O4—-[1]McConnell RM, et al. Inhibition studies of some serine and thiol proteinases by new leupeptin analogues. J Med Chem. 1993 Apr 16;36(8):1084-9.|[2]Wang YR, et al. Cathepsin L plays a role in quinolinic acid-induced NF-Κb activation and excitotoxicity in rat striatal neurons. PLoS One. 2013 Sep 20;8(9):e75702.–147600-40-6–384.51—-CC(C)C[C@H](NC(C)=O)C(N[C@@H](C(C)C)C(N[C@H](C=O)CCCCN)=O)=O–Neurological Disease–10 mM in DMSO–Cathepsin–Cathepsin B–Metabolic Enzyme/Protease–Peptides