Description

Ac-?IETD-?CHO is a potent, reversible inhibitor of granzyme B and caspase-8. Ac-?IETD-?CHO inhibits Fas-mediated apoptotic cell death, hemorrhage, and liver failure. Ac-?IETD-?CHO also inhibits cytotoxic T lymphocytes induced cell death[1][2].—–C21H34N4O10—-[1]Hayashida M, et al. Cell death induction by CTL: perforin/granzyme B system dominantly acts for cell death induction in human hepatocellular carcinoma cells. Proc Soc Exp Biol Med. 2000 Nov;225(2):143-50.|[2]Bajt ML, et al. Protection against Fas receptor-mediated apoptosis in hepatocytes and nonparenchymal cells by a caspase-8 inhibitor in vivo: evidence for a postmitochondrial processing of caspase-8. Toxicol Sci. 2000 Nov;58(1):109-17.–191338-86-0–502.52—-CC[C@H](C)[C@H](NC(C)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@H](O)C)C(N[C@H](C=O)CC(O)=O)=O)=O)=O–Cancer–10 mM in DMSO–Apoptosis—-Apoptosis–Peptides