Description

A 419259 GMP is the GMP grade A 419259 (HY-15764), inducing cell apoptosis. GMP-grade small molecules can be used as auxiliary reagents in cell therapy. A 419259 (RK-20449) is a broad-spectrum pyrrole-pyrimidine inhibitor targeting Src, Lck, and Lyn with IC50s of 9 nM, <3 nM, and <3 nM, respectively[1][2].–Applications–Formula-C29H34N6O-Citation–References-[1]Wilson MB, et al. Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis. Oncogene. 2002 Nov 21;21(53):8075-88.|[2]Zhang X, et al. Src-family tyrosine kinase activities are essential for differentiation of human embryonic stem cells. Stem Cell Res. 2014 Nov;13(3 Pt A):379-89.-CASNumber-364042-47-7-MolecularWeight-482.62-Compound Purity–SMILES-NC1=C2C(N([C@H]3CC[C@H](N4CCN(C)CC4)CC3)C=C2C5=CC=C(OC6=CC=CC=C6)C=C5)=NC=N1-Research_Area-Cancer-Solubility-10 mM in DMSO-Target-Apoptosis;Src-Isoform–Pathway-Apoptosis;Protein Tyrosine Kinase/RTK-MCE Product type-GMP Small Molecules