Description

6,7-Dihydroxy-4-coumarinylacetic acid is a potent and selective inhibitor of ALR2. 6,7-Dihydroxy-4-coumarinylacetic acid inhibits ALR2, SDH andALR1 with IC50s of 9.6, 288 and 66.3 μM, respectively. 6,7-Dihydroxy-4-coumarinylacetic acid clearly suppresses galactitol accumulation[1].–Applications–Formula-C11H8O6-Citation–References-[1]Kato A, et al. 6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5630-3.-CASNumber-88404-14-2-MolecularWeight-236.18-Compound Purity–SMILES-O=C(O)CC(C1=CC(O)=C(O)C=C1O2)=CC2=O-Research_Area-Metabolic Disease-Solubility-10 mM in DMSO-Target-Aldose Reductase-Isoform–Pathway-Metabolic Enzyme/Protease-MCE Product type-Dye Reagents