Description

4-N3Pfp-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. 4-N3Pfp-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.–Applications-Cancer-programmed cell death-Formula-C11H4F4N4O4-Citation–References–CASNumber-126695-58-7-MolecularWeight-332.17-Compound Purity–SMILES-O=C(ON1C(CCC1=O)=O)C2=C(F)C(F)=C(N=[N+]=[N-])C(F)=C2F-Research_Area-Cancer-Solubility-10 mM in DMSO-Target-ADC Linker-Isoform-Non-cleavable Linker-Pathway-Antibody-drug Conjugate/ADC Related-MCE Product type-ADC Related