Description

4-Hydroperoxy Cyclophosphamide-d4 is the deuterium labeled 4-Hydroperoxy cyclophosphamide. 4-Hydroperoxy cyclophosphamide is the active metabolite form of the proagent Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide has the potential for lymphomas and autoimmune disorders[1][2].–80°C, stored under nitrogen-Applications-COVID-19-anti-virus-Formula-C7H11D4Cl2N2O4P-Citation–References-[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG-CASNumber-1246816-71-6-MolecularWeight-297.11-Compound Purity-95.0-SMILES-N(CC(Cl)([2H])[2H])(CC(Cl)([2H])[2H])P1(=O)NC(OO)CCO1-Research_Area-Inflammation/Immunology-Solubility-10 mM in DMSO-Target-Apoptosis;DNA Alkylator/Crosslinker;Drug Metabolite;Reactive Oxygen Species-Isoform–Pathway-Apoptosis;Cell Cycle/DNA Damage;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB-MCE Product type-Isotope-Labeled Compounds