Description

16α-Hydroxyprednisolone-d3 is the deuterium labeled 16α-Hydroxyprednisolone. 16α-Hydroxyprednisolone is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid budesonide via cytochrome P450 3A (CYP3A) enzymes[1][2].–Applications–Formula-C21H25D3O6-Citation–References-[1]Xavier Matabosch, et al. Identification of budesonide metabolites in human urine after oral administration. Anal Bioanal Chem. 2012 Aug;404(2):325-40.|[2]G Jönsson, et al. Budesonide is metabolized by cytochrome P450 3A (CYP3A) enzymes in human liver. Drug Metab Dispos. 1995 Jan;23(1):137-42.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. -CASNumber–MolecularWeight-379.46-Compound Purity–SMILES-C[C@@]12[C@](C[C@H]([C@]2(O)C(CO)=O)O)([H])[C@@]3([H])[C@]([C@@]4(C(CC3)=CC(C=C4)=O)C)([H])[C@@](C1([2H])[2H])([2H])O-Research_Area-Inflammation/Immunology-Solubility-10 mM in DMSO-Target-Drug Metabolite;Isotope-Labeled Compounds-Isoform–Pathway-Metabolic Enzyme/Protease;Others-MCE Product type-Isotope-Labeled Compounds