Description

γ-Amanitin an ADC cytotoxin and isolated from the mushroom. γ-Amanitin inhibits RNA polymerase II and disrupts synthesis of mRNA. γ-Amanitin shows similar effects to α-Amanitin and β-Amanitin. γ-Amanitin competitively binds to monoclonal antibody (mAb), with an IC50 of 163.1 ng/mL[1].-Solution, -20°C, 2 years-Applications-Cancer-programmed cell death-Formula-C39H54N10O13S-Citation–References-[1]He K, et al. Production of a broad-specificity monoclonal antibody and application as a receptor to detection amatoxins in mushroom. Biologicals. 2017 Sep;49:57-61. -CASNumber-21150-23-2-MolecularWeight-902.97-Compound Purity–SMILES-O=[S](C[C@H](NC(CNC1=O)=O)C(N[C@H](C2=O)CC(N)=O)=O)C(N3)=C(C[C@@H](C(NCC(N[C@H]1[C@@H](C)CC)=O)=O)NC([C@@H](NC([C@H](C4)N2C[C@@H]4O)=O)[C@@H](C)[C@@H](O)C)=O)C(C3=C5)=CC=C5O-Research_Area-Cancer-Solubility-10 mM in DMSO-Target-ADC Cytotoxin;DNA/RNA Synthesis-Isoform-Traditional Cytotoxic Agents-Pathway-Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage-MCE Product type-ADC Related