Description

α-MSH free acid (α-Melanocyte-Stimulating Hormone free acid) is an MC3R and MC4R agonist with EC50s of 0.16 nM and 5.6 nM, respectively. α-MSH free acid activates cAMP generation at MC3R and MC4R[1].—Neuroscience-Neuromodulation–C77H108N20O20S—-[1]Miwa H, et al. Structural determinants of the melanocortin peptides required for activation of melanocortin-3 and melanocortin-4 receptors. J Pharmacol Exp Ther. 1995;273(1):367-372.–10466-28-1–1665.87—-OC(C=C1)=CC=C1C[C@H](NC([C@H](CO)NC(C)=O)=O)C(N[C@@H](CO)C(N[C@@H](CCSC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC2=CN=CN2)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(N[C@@H](CCCCN)C(N4[C@@H](CCC4)C(N[C@H](C(O)=O)C(C)C)=O)=O)=O)=O)CC5=CNC6=CC=CC=C56)=O)=O)=O)=O)=O)=O)=O–Neurological Disease–10 mM in DMSO–Melanocortin Receptor–MC3R;MC4R–GPCR/G Protein;Neuronal Signaling–Peptides