α-Conotoxin PnIA (TFA)-1 mg

Description

α-Conotoxin PnIA TFA, a potent and selective antagonist of the mammalian α7 nAChR, has the potential for the research of neurological conditions such as neuropathic pain and Alzheimer’s disease[1].–80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)–Neuroscience-Neurodegeneration–C67H96F3N19O24S4—-[1]Gene Hopping, et al. Hydrophobic Residues at Position 10 of α-conotoxin PnIA Influence Subtype Selectivity Between α7 and α3β2 Neuronal Nicotinic Acetylcholine Receptors. Biochem Pharmacol. 2014 Oct 15;91(4):534-42.—-1736.82–96.83–O=C1[C@@]2([H])N(CCC2)C([C@@H](NC([C@@H](NC([C@@]3([H])NC([C@H](CSSC[C@](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N4[C@](CCC4)([H])C(N[C@H](C(N[C@H](C(N[C@@H](CSSC3)C(N)=O)=O)CC5=CC=C(C=C5)O)=O)CC(O)=O)=O)=O)CC(N)=O)=O)CC(N)=O)=O)C)=O)C)=O)([H])NC([C@@]6([H])N1CCC6)=O)NC(CN)=O)=O)=O)CO)=O)CC(C)C)=O.OC(C(F)(F)F)=O–Neurological Disease–DMSO : 100 mg/mL (ultrasonic)–nAChR—-Membrane Transporter/Ion Channel;Neuronal Signaling–Peptides