α-Conotoxin MII-1 mg

Description

α-Conotoxin MII (α-CTxMII), a 16-amino acid peptide from the venom of the marine snail Conus magus, potently blocks nicotinic acetylcholine receptors (nAChRs) composed of α3β2 subunits, with an IC50 of 0.5 nM. α-Conotoxin MII (α-CTxMII) potently blocks β3-containing neuronal nicotinic receptors [1][2][3].–80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)–Neuroscience-Neuromodulation–C67H103N23O22S4—-[1]J M McIntosh, et al. Conus Peptides: Novel Probes for Nicotinic Acetylcholine Receptor Structure and Function. Eur J Pharmacol. 2000 Mar 30;393(1-3):205-8.|[2]G E Cartier, et al. A New Alpha-Conotoxin Which Targets alpha3beta2 Nicotinic Acetylcholine Receptors. J Biol Chem. 1996 Mar 29;271(13):7522-8.|[3]S C Harvey, et al. Determinants of Specificity for Alpha-Conotoxin MII on alpha3beta2 Neuronal Nicotinic Receptors. Mol Pharmacol. 1997 Feb;51(2):336-42.–175735-93-0–1710.94–98.53–O=C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC2=CNC=N2)C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@H]3CC(C)C)=O)=O)=O)=O)=O)=O)=O)NC4=O)C(N[C@@H](CSSC[C@@H](C(N)=O)NC3=O)C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N5[C@@H](CCC5)C(N[C@H]4C(C)C)=O)=O)=O)=O)=O)CN–Neurological Disease–10 mM in DMSO–nAChR—-Membrane Transporter/Ion Channel;Neuronal Signaling–Peptides