Description

Fmoc-His(3-Me)OH derives Histidine-associating compounds with biological activity. Fmoc-His(3-Me)OH, with Fmoc-citrulline-OH, Fmoc-His(1-Me)-OH together, forms tri-peptides and shows vasodilating effect with EC50s of 2.7-4.7 mM in 1.0 mM Phenylephrine (PE)-contracted aorta rings. Fmoc-His(3-Me)OH (resin) also makes Methyl-His-Gly-Lys (His(3-Me)-Gly-Lys), thus acts as an [Ca2+]i inhibitor. Fmoc-His(3-Me)OH methylates NAHIS02, making it unable to block the Alzheimer’s Aβ channel[1][2][3].–20°C, 3 years; 4°C, 2 years (Powder)–Neuroscience-Neurodegeneration–C22H21N3O4—-[1]Tanaka M, et al. His-Arg-Trp potently attenuates contracted tension of thoracic aorta of Sprague-Dawley rats through the suppression of extracellular Ca2+ influx. Peptides. 2009 Aug;30(8):1502-7.|[2]Kumrungsee T, et al. Identification of peptides from soybean protein, glycinin, possessing suppression of intracellular Ca2+ concentration in vascular smooth muscle cells. Food Chem. 2014;152:218-24. |[3]Arispe N, et al. Efficiency of histidine-associating compounds for blocking the alzheimer’s Abeta channel activity and cytotoxicity. Biophys J. 2008 Nov 15;95(10):4879-89. –252049-16-4–391.42–98.0–O=C(O)[C@H](CC1=CN=CN1C)NC(OCC2C3=C(C4=C2C=CC=C4)C=CC=C3)=O–Cardiovascular Disease–10 mM in DMSO–Amino Acid Derivatives;Amyloid-β—-Neuronal Signaling;Others–Peptides