Description

VSGLNPSLWSIFGLQFILLWLVSGSRHYLW is a 30-amino-acid peptide mimicking the C-terminal domain of α2δ-1, termed as α2δ-1Tat peptide. VSGLNPSLWSIFGLQFILLWLVSGSRHYLW can effectively interrupt the α2δ-1 – NMDAR interaction in vitro and in vivo. VSGLNPSLWSIFGLQFILLWLVSGSRHYLW can be used for researching neuropathic pain[1].—Neuroscience-Neurodegeneration–C171H250N40O39—-[1]Chen Y, et al. Increased α2δ-1-NMDA receptor coupling potentiates glutamatergic input to spinal dorsal horn neurons in chemotherapy-induced neuropathic pain. J Neurochem.–2279952-25-7–3490.06—-O=C([C@H]1N(CCC1)C([C@H](CC(N)=O)NC([C@H](CC(C)C)NC(CNC([C@H](CO)NC([C@@H](N)C(C)C)=O)=O)=O)=O)=O)N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](CC2=CNC3=CC=CC=C23)C(N[C@@H](CO)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC4=CC=CC=C4)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC5=CC=CC=C5)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CO)C(NCC(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(O)=O)CC6=CNC7=CC=CC=C67)=O)=O)CC8=CC=C(C=C8)O)=O)CC9=CN=CN9)=O)=O)=O)=O)=O)=O)=O)CC=CNC=CC=CC=C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O–Neurological Disease–10 mM in DMSO–iGluR—-Membrane Transporter/Ion Channel;Neuronal Signaling–Peptides