Description

GpTx-1 is a potent and selective NaV1.7 antagonist with an IC50 of 10 nM[1].—–C176H271N53O45S7—-[1]Murray JK, et al. Engineering potent and selective analogues of GpTx-1, a tarantula venom peptide antagonist of the Na(V)1.7 sodium channel. J Med Chem. 2015 Mar 12;58(5):2299-314.–1661050-12-9–4073.82—-O=C([C@@H](N)CC(O)=O)N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2CSSC[C@H](NC3=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CC4=CC=CC=C4)=O)C(C)C)=O)CC5=CC=C(O)C=C5)=O)CCCCN)=O)=O)CCCCN)=O)CC(O)=O)=O)CC(N)=O)=O)CC(O)=O)=O)CCC1)=O)[C@H](CC)C)=O)CSSC[C@H](NC6=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]3CC7=CNC8=CC=CC=C78)=O)CCCCN)=O)CC9=CNC=N9)=O)[C@@H](C)O)=O)CCCNC(N)=N)=O)CO)=O)=O)CCCCN)=O)CCCNC(N)=N)=O)CCSC)=O)CC=CC=CC=C)=O)=O)CC(C)C)=O)CSSC[C@H](NC2=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]6C(C)C)=O)CC(C)C)=O)CC(N)=O)=O)CCC)=O)CCCNC(N)=N)=O–Neurological Disease–10 mM in DMSO–Sodium Channel—-Membrane Transporter/Ion Channel–Peptides