GR 64349-10 mg

Description

GR 64349 is a potent and highly selective NK2 receptor peptide antagonist, with an EC50 of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK1 and NK3 receptors, respectively[1][2].–80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)–Neuroscience-Neuromodulation–C42H68N10O11S—-[1]Y Chang, et al. Tachykinin receptor subtypes in the isolated guinea pig heart and their role in mediating responses to neurokinin A. J Pharmacol Exp Ther. 2000 Jul;294(1):147-54.|[2]M J Deal, et al. Conformationally constrained tachykinin analogues: potent and highly selective neurokinin NK-2 receptor agonists. J Med Chem. 1992 Oct 30;35(22):4195-204.–137593-52-3–921.11–99.45–CSCC[C@@H](C(N)=O)NC([C@@H](N1C([C@@H](CC1)NC([C@H](C(C)C)NC([C@@H](NC([C@H](CO)NC([C@H](CC(O)=O)NC([C@@H](N)CCCCN)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O)CC(C)C)=O–Neurological Disease–10 mM in DMSO–Neurokinin Receptor—-GPCR/G Protein;Neuronal Signaling–Peptides