Description

Astressin is a potent corticotropin releasing factor (CRF) antagonist.–80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)–Neuroscience-Neuromodulation–C161H269N49O42—-[1]Gulyas J, et al. Potent, structurally constrained agonists and competitive antagonists of corticotropin-releasing factor. Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10575-9.|[2]Spina MG, et al. Behavioral effects of central administration of the novel CRF antagonist astressin in rats. Neuropsychopharmacology. 2000 Mar;22(3):230-9.|[3]Maecker H, et al. Astressin, a novel and potent CRF antagonist, is neuroprotective in the hippocampus when administered after a seizure. Brain Res. 1997 Jan 2;744(1):166-70.–170809-51-5–3563.16–98.93–[C@H](CC1=CN=CN1)(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]2C(=O)N[C@@H](C)C(=O)N[C@@H](CC3=CN=CN3)C(=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]([C@H](CC)C)C(N)=O)=O)[C@H](CC)C)=O)CCC(O)=O)=O)CCCC)=O)CC(C)C)=O)CCCCN)=O)CCCNC(=N)N)=O)CC(N)=O)=O)CCCCNC(=O)CC2)=O)CCC(N)=O)=O)C)=O)CC(C)C)=O)CCC(N)=O)=O)CCC(O)=O)=O)C)=O)CCCNC(=N)N)=O)C)=O)CCCC)=O)CCC(O)=O)=O)CC(C)C)=O)C(C)C)=O)CCC(O)=O)=O)CCCNC(=N)N)=O)CC(C)C)=O)CC(C)C)=O)NC([C@@H](CC4=CC=CC=C4)N)=O–Neurological Disease–H2O : 18.18 mg/mL (ultrasonic;adjust pH to 4 with HCl)–Others—-Others–Peptides