Description

L-Homocysteic acid (L-HCA) is an endogenous excitatory amino acid that acts as a NMDA receptor agonist (EC50: 14 μM). L-Homocysteic acid is neurotoxic, and can be used in the research of neurological disorders[1][2][3].—Neuroscience-Neurodegeneration–C4H9NO5S—-[1]M Yuzaki, et al. Characterization of L-homocysteate-induced currents in Purkinje cells from wild-type and NMDA receptor knockout mice. J Neurophysiol . 1999 Nov;82(5):2820-6. |[2]J W Olney, et al. L-homocysteic acid: an endogenous excitotoxic ligand of the NMDA receptor. Brain Res Bull. 1987 Nov;19(5):597-602. |[3]B Lockhart, et al. Inhibition of L-homocysteic acid and buthionine sulphoximine-mediated neurotoxicity in rat embryonic neuronal cultures with alpha-lipoic acid enantiomers. Brain Res. 2000 Feb 14;855(2):292-7. |[4]P Mares, et al. Convulsant action of D,L-homocysteic acid and its stereoisomers in immature rats. |[5]Katherine L Nicholson, et al. The discriminative stimulus effects of N-methyl-D-aspartate glycine-site ligands in NMDA antagonist-trained rats. Psychopharmacology (Berl). 2009 Apr;203(2):441-51. –14857-77-3–183.18—-O=C(O)[C@@H](N)CCS(=O)(O)=O–Neurological Disease–10 mM in DMSO–iGluR–NMDA Receptor–Membrane Transporter/Ion Channel;Neuronal Signaling–Peptides