Description
Mc-Val-Cit-PABC-PNP is a cathepsin cleavable linker for antibody-drug conjugates (ADCs) which couples the antibody element to the effecting compound. Mc-Val-Cit-PABC-PNP can be used in the synthesis of ADCs[1][2].-4°C (Powder, protect from light, stored under nitrogen)-Applications-Cancer-programmed cell death-Formula-C35H43N7O11-Citation–References-[1]Li Y, et al. Discovery of novel antibody-drug conjugates bearing tissue protease specific linker with both anti-angiogenic and strong cytotoxic effects. Bioorg Chem. 2023 Aug;137:106575.|[2]Che-Leung Law et al. Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders.Patent WO2005081711A2.-CASNumber-159857-81-5-MolecularWeight-737.76-Compound Purity-98.89-SMILES-CC(C)[C@@H](C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(COC(OC2=CC=C([N+]([O-])=O)C=C2)=O)C=C1)=O)=O)NC(CCCCCN3C(C=CC3=O)=O)=O-Research_Area-Cancer; Inflammation/Immunology; Others-Solubility-DMSO : ≥ 37 mg/mL-Target-ADC Linker-Isoform-Cleavable Linker;Protease Cleavable Linker-Pathway-Antibody-drug Conjugate/ADC Related-MCE Product type-ADC Related
