Description

Ac-DArg-c[Cys-Glu-His-DPhe-Arg-Trp-Cys]-NH 2 is a cyclic octapeptide with MC4R agonism. Ac-DArg-c[Cys-Glu-His-DPhe-Arg-Trp-Cys]-NH 2 significantly increases heart rate and blood pressure[1].—–C51H70N18O11S2—-[1]Doering SR, et al. Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput “Unbiased” Screening Campaign. J Med Chem. 2021 May 13;64(9):5577-5592. doi: 10.1021/acs.jmedchem.0c02041. Epub 2021 Apr 22. Erratum in: J Med Chem. 2023 May 25;66(10):7063-7065.–819048-44-7–1175.35—-O=C([C@@H](NC([C@H](NC([C@@H](NC([C@@H](NC([C@H](CSSC[C@H](NC1=O)C(N)=O)NC([C@H](NC(C)=O)CCCNC(N)=N)=O)=O)CCC(O)=O)=O)CC2=CN=CN2)=O)CC3=CC=CC=C3)=O)CCCNC(N)=N)N[C@H]1CC4=CNC5=CC=CC=C45–Cardiovascular Disease–10 mM in DMSO–Melanocortin Receptor—-GPCR/G Protein;Neuronal Signaling–Peptides